AKG

One of the most interesting substances is alpha-ketoglutarate. It is very often advertised as a life-prolonging agent, and indeed, all the studies conducted so far have shown its effectiveness.

At first there were studies on fruit flies, giving quite promising results, the animals lived a little longer. But where the fly and where the human, quite different organisms, different metabolism. Then came mammal studies, and here, too, there was success, laboratory mice lived longer and became sick less often. The most interesting, however, was a study involving humans:

https://www.aging-us.com/article/203736/text

Where just 7 months of supplementation turned the biological clock back 8 years!

The question arises, are the reports too optimistic? A number of doubts can be raised, most notably whether the method of measuring the “biological clock” adopted by the researchers actually reflects the age of the body. Unfortunately, there is almost certainly no such simple translation, and as a result of supplementation, people’s age did not regress, only the index, since a supplement was used that affects this very index. There was no restoration of bone density, no reversal of wrinkles, no change in telomeres. Unfortunately, studies sponsored by manufacturers of various specifics are often worthless, and this applies to both dietary supplements and normal drugs prescribed by doctors.

The fact remains, however, animals that received it lived longer. Here, however, there may be a problem with the fact that laboratory animals usually have neither a good diet nor conditions, let alone medical care. It is not certain that the effect in humans would be the same, or at least strongly similar.

What can be said? It’s certainly worth taking AKG, with the cheap arginine-linked form, popular in stores and pharmacies, in doses of 3 – 4 grams twice a day, being completely sufficient. The fact is that as we age, the synthesis of AKG in the human body decreases, the fact is that this substance is responsible for a whole range of reactions that support our health. You can expect a slower appearance of wrinkles, and even a gentle reversal of those that have formed (yes, there is a study in which AKG reversed wrinkles, but this involved a cream and it is not known whether a supplement will have a similar effect). There will be slower wear and tear on joints, and there won’t be as much degeneration of the surface of blood vessels, which to some extent should protect against both atherosclerosis and stroke. Some degenerative processes of the nervous system should be slowed down.

However, I would not expect miracles, and certainly not rejuvenation by any number of years. The changes, if there are any, are rather small and unnoticeable in months. These types of substances, if they work, it is imperceptible to us, because everything happens very slowly. If you take monozygotic twins, give one of them a rejuvenating supplement, then yes, the change would be visible, but after, say, 30 years.

Instead of this human study, where no health status was measured, only the indicator most sensitive to the supplement’s effect, a study on mice, where the focus was already on the indicator of most interest, life expectancy, would be better included in the performance evaluation:

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30417-4

The life expectancy of the animals increased by about 10%, a very good result indeed, with the suspected mechanism behind this being a reduction in chronic inflammation.